Via 'Science' online: http://www.sciencemag.org/cgi/content/full/317/5839/757
The full report is here: http://www.sciencemag.org/cgi/reprin...7/5839/819.pdfn a new approach, Airan et al. report on page 819 of this issue the use of optical imaging to capture cellular activity at millisecond resolution in brain slices (2). Their study, which uses rodents with some of the behavioral features of depression, does not define the neurobiology of depression in humans, but it demonstrates how optical imaging--in this case, using voltage-sensitive dyes--can identify changes in brain activity, enabling correlations between real-time cellular activity and changing affective state.
Differences in neuroanatomy and physiology between rodents and humans mean that this model will only be an approximation of what occurs in depressed humans and will not explore all of the neurophysiological changes that occur with depression.
It is a start, however.