What predictions can we make concerning our future, over the course of thousands, millions and billions of years?
Can we extrapolate known trends in genetics?
Will the human race ever diverge into separate species?
Or will it eventually become homogenous?
How long will it be before we accumulate enough traits to evolve into a new species?
Geological questions are also pertinent:
How will the continents change over the next few hundred million years?
How will this effect climate?
How long before we experience a geological catastrophe, such as a supereruption or a massive impact?
How long before all large wild animals and plants are extinct?
Will we create a "garden world" where all the ecology is geared to our own consumption?
Will we ever experience a massive astronomical catastrophe, such as a gamma ray burst?
How long before the Sun's expansion increases Earth's UV radiation levels beyond human tolerance?
How long before the Earth becomes like Venus?
How long before the Earth is finally destroyed?