OK, some scientist in a military lab goes "Oops" and drops a sealed vial, breaking it. Within a year, all members of the Primate Order have died in the resulting pandemic. Will there ever be a 2004-level civilization again? What if it is all the mammals, or even all the vertebrates, die? Will a new technophilic sapient species evolve? Will natural resources recover? Does the biosphere have enough time?