It makes sense to start with the most easy to find references possible to make the initial alignment as certain as possible.
Originally Posted by Glom
So find the Sun (if you can't find the Sun, your navigation is such that you're on the way to visit some apes) to fix the circle on which Canopus will lie, find Canopus and you're already within the precision range where the computer can help you find the other references.
Reductionist and proud of it.
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Chase after the truth like all hell and you'll free yourself, even though you never touch its coat tails. Clarence Darrow
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