I've often wondered and checked to see if someone has done any studies or experiments to see if a population of microscopic organisms or bacteria have ever been forced to slowly undergo changes to see if forced evolution can be triggered. For example, taking an organism known to not be able to survive in extreme conditions and slowly changing a controlled environment over many generations from one they thrive in to the extreme one (relative to the organism). If so, I would love to see any work being done in this area.
Here are a couple of items I have found on the subject if anyone is interested:
Electronics Weekly from 2009
From the NIH
List of known genome sequences
It would be a bit like dog breeding, picking the 'best' subset of a greater population and breeding those and so on, except this would be about adaptation to an environment rather than an aesthetic one or one that is meant to exploit the production of a specific product of the species for medical or industrial benefit.
In my head, I imagine an organism changing from its natural environment to an environment that matches a specific environment on Mars or Venus or even an artificial environment that doesn't exist anywhere that we know of. It would give us a greater knowledge of both evolution and a better understanding of what can exist in various conditions.